Positive rectal swabs in young patients recovered from coronavirus disease 2019 (COVID-19)
Identifieur interne : 000280 ( Main/Exploration ); précédent : 000279; suivant : 000281Positive rectal swabs in young patients recovered from coronavirus disease 2019 (COVID-19)
Auteurs : Bin Zhang [République populaire de Chine] ; Shuyi Liu [République populaire de Chine] ; Yuhao Dong [République populaire de Chine] ; Lu Zhang [République populaire de Chine] ; Qingyang Zhong [République populaire de Chine] ; Yujian Zou [République populaire de Chine] ; Shuixing Zhang [République populaire de Chine]Source :
- The Journal of Infection [ 0163-4453 ] ; 2020.
Abstract
To investigate the widely concerned issue about positive real-time reverse transcription polymerase chain reaction (RT-PCR) test results after discharge in patients recovered from coronavirus disease 2019 (COVID-19).
We identified seven cases of COVID-19 who was readmitted to hospital because of positive RT-PCR after discharge, including three pediatrics and four young adult patients.
Six patients had positive rectal swabs but negative throat swabs, and one patient had positive throat swabs. All the patients continued to be asymptomatic and had unchanged chest computed tomography from previous images. The time from hospital discharge to positive RT-PCR after recovery was 7–11 days. The time from positive to negative rectal swabs was 5-23 days.
The study might suggest the positive RT-PCR after recovery did not mean disease relapse or virus reinfection. Adding RT-PCR test of rectal swabs to the criteria for discharge or discontinuation of quarantine might be necessary.
Url:
DOI: 10.1016/j.jinf.2020.04.023
PubMed: 32335176
PubMed Central: 7177113
Affiliations:
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(COVID-19)</title><author><name sortKey="Zhang, Bin" sort="Zhang, Bin" uniqKey="Zhang B" first="Bin" last="Zhang">Bin Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff0001">The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Shuyi" sort="Liu, Shuyi" uniqKey="Liu S" first="Shuyi" last="Liu">Shuyi Liu</name><affiliation wicri:level="1"><nlm:aff id="aff0001">The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Yuhao" sort="Dong, Yuhao" uniqKey="Dong Y" first="Yuhao" last="Dong">Yuhao Dong</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Guangdong Provincial People's Hospital/Guangdong academy of medical sciences, Guangzhou, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial People's Hospital/Guangdong academy of medical sciences, Guangzhou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Lu" sort="Zhang, Lu" uniqKey="Zhang L" first="Lu" last="Zhang">Lu Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff0001">The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Zhong, Qingyang" sort="Zhong, Qingyang" uniqKey="Zhong Q" first="Qingyang" last="Zhong">Qingyang Zhong</name><affiliation wicri:level="1"><nlm:aff id="aff0003">Dongguan Ninth People's Hospital, Dongguan, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dongguan Ninth People's Hospital, Dongguan, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Zou, Yujian" sort="Zou, Yujian" uniqKey="Zou Y" first="Yujian" last="Zou">Yujian Zou</name><affiliation wicri:level="1"><nlm:aff id="aff0004">Dongguan People's Hospital, Dongguan, Dongguan, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dongguan People's Hospital, Dongguan, Dongguan, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Shuixing" sort="Zhang, Shuixing" uniqKey="Zhang S" first="Shuixing" last="Zhang">Shuixing Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff0001">The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of Infection</title><idno type="ISSN">0163-4453</idno><idno type="eISSN">1532-2742</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>To investigate the widely concerned issue about positive real-time reverse transcription polymerase chain reaction (RT-PCR) test results after discharge in patients recovered from coronavirus disease 2019 (COVID-19).</p></sec><sec><title>Methods</title><p>We identified seven cases of COVID-19 who was readmitted to hospital because of positive RT-PCR after discharge, including three pediatrics and four young adult patients.</p></sec><sec><title>Results</title><p>Six patients had positive rectal swabs but negative throat swabs, and one patient had positive throat swabs. All the patients continued to be asymptomatic and had unchanged chest computed tomography from previous images. The time from hospital discharge to positive RT-PCR after recovery was 7–11 days. The time from positive to negative rectal swabs was 5-23 days.</p></sec><sec><title>Conclusion</title><p>The study might suggest the positive RT-PCR after recovery did not mean disease relapse or virus reinfection. Adding RT-PCR test of rectal swabs to the criteria for discharge or discontinuation of quarantine might be necessary.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name></author><author><name sortKey="Hu, B" uniqKey="Hu B">B. Hu</name></author><author><name sortKey="Hu, C" uniqKey="Hu C">C. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, X" uniqKey="Xie X">X. 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Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Du, R H" uniqKey="Du R">R.H. Du</name></author><author><name sortKey="Li, B" uniqKey="Li B">B. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, X" uniqKey="Guo X">X. Guo</name></author><author><name sortKey="Guo, Z" uniqKey="Guo Z">Z. Guo</name></author><author><name sortKey="Duan, C" uniqKey="Duan C">C. Duan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author><author><name sortKey="Lou, J" uniqKey="Lou J">J. Lou</name></author><author><name sortKey="Bai, Y" uniqKey="Bai Y">Y. Bai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Guo, C" uniqKey="Guo C">C. Guo</name></author><author><name sortKey="Tang, L" uniqKey="Tang L">L. Tang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Bin" sort="Zhang, Bin" uniqKey="Zhang B" first="Bin" last="Zhang">Bin Zhang</name></noRegion><name sortKey="Dong, Yuhao" sort="Dong, Yuhao" uniqKey="Dong Y" first="Yuhao" last="Dong">Yuhao Dong</name><name sortKey="Liu, Shuyi" sort="Liu, Shuyi" uniqKey="Liu S" first="Shuyi" last="Liu">Shuyi Liu</name><name sortKey="Zhang, Lu" sort="Zhang, Lu" uniqKey="Zhang L" first="Lu" last="Zhang">Lu Zhang</name><name sortKey="Zhang, Shuixing" sort="Zhang, Shuixing" uniqKey="Zhang S" first="Shuixing" last="Zhang">Shuixing Zhang</name><name sortKey="Zhong, Qingyang" sort="Zhong, Qingyang" uniqKey="Zhong Q" first="Qingyang" last="Zhong">Qingyang Zhong</name><name sortKey="Zou, Yujian" sort="Zou, Yujian" uniqKey="Zou Y" first="Yujian" last="Zou">Yujian Zou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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